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Sun exposure is the largest environmental accelerant of skin aging, primarily through UV-driven DNA damage in keratinocytes and free radical generation that degrades collagen

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Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner

Both compounds would benefit significantly from independent replication, chronic safety studies, and -- if warranted by safety data -- carefully designed early human studies

HFD-fed DUSP3 KO mice display the induction of body weight, liver mass, serum cholesterol levels, hepatic lipid accumulation, insulin resistance, and liver injury compared to those of HFD-fed wild-type mice